金山科研平台授权一级代理，询价咨询微信jinshanbio miltenyi美天旎Human IL-2 IS细胞因子品牌：Miltenyi（美天旎）货号：130-097-748CAS号：详见说明书供应商：Miltenyi（美天旎）保质期：详见说明书保存条件：详见说明书规格：EA

金山科研平台,咨询微信：jinshanbio询价，现货促销

miltenyi美天旎Human IL-2 IS细胞因子，miltenyi美天旎Human IL-2 IS细胞因子，

IL-2 IS stands for interleukin 2 "Improved Sequence", also termed aldesleukin, and is a variant of IL-2 with a serine to cysteine substitution. Human IL-2 IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays, and possesses the same properties as naturally occurring IL-2.

Background information

IL-2, a potent lymphoid cell growth factor, is a typical four α-helix bundle cytokine. It is produced by activated T cells, especially the CD4+T helper cell population. It plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes proliferation and differentiation of T cells, NK cells and B cells and is involved in the elimination of self-reactive T cells. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β- chain, and common γ-chain. The latter two are also used for IL-15 signaling.

Biological activity

Proliferation of CTLL-2 cells (NIBSC 86/504)

research grade: ≥ 3×106IU/mg

premium grade: ≥ 5×106IU/mg

Quality description

Research-gradecytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Premium-gradecytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).