IFN alpha Monoclonal Antibody (EBI-1), eBioscience/IFNα单克隆抗体（EBI-1）

货号：BMS160

规格：100 µg

价格：2806

产品类型：抗体和ELISA

品牌：eBioscience

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	Assay-Dependent（ELISA)；Assay-Dependent(FN)

产品详细信息Description: Anti-Human IFN-alpha (EBI-1) inhibits the antiviral activity of interferon alpha. BMS160 specifically reacts with human recombinant and natural interferon alpha and can be used as capture antibody in ELISA.Applications Tested: ELISA, Functional Studies (Blocking).Source: E. coli (amino acids Ser113-Ala271; accession # NP_000566).Bioactivity: The ED50 of this protein, as measured by proliferation of mouse D10S cells, is less than or equal to 0.001 ng/mL, whichcorresponds to a specific activity of at least 1.0 x 10e9 Units/mg.Endotoxin: Less than 0.1 ng/ug cytokine as determined by the LAL assay. Purity: >98% as determined by SDS-PAGE and HPLC.Molecular Weight: 18 kDa.Storage and handling: For best recovery, quick spin vial prior to opening. Use in sterile environment. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex.靶标信息IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.

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