ATRX Monoclonal Antibody (CL0537)

货号：MA5-24609

规格：100 µL

价格：5548

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein corresponding to Human ATRX

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：CL0537

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1.0mg/mL	用法：	2-10 µg/mL（ICC）；2-10 µg/mL(IF);1:200-1:500(IHC）；1 µg/mL（WB）

产品详细信息Immunogen sequence: AAWAEYEAEK KGLTMRFNIP TGTNLPPVSF NSQTPYIPFN LGALSAMSNQ QLEDLINQGR EKVVEATNSV TAVRIQPLED IISAVWKENM NLSEAQVQAL ALSRQASQEL DVKRREAIYN DVLTKQQMLI SCVQRILMNR RHighest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.靶标信息ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

数据：

ATRX Antibody (MA5-24609) in IFImmunofluorescence staining of RAD54 in U251 cell line using a RAD54 Monoclonal Antibody (Product # MA5-24609), showing clear nuclear (without nucleoli) staining in green. Microtubule- and nuclear probes are visualized in red and blue respectively (where available). ATRX Antibody (MA5-24609) in IHCImmunohistochemical staining of ATRX in human fallopian tube using ATRX Monoclonal Antibody (CL0537) (Product # MA5-24609) shows strong nuclear positivity in glandular cells. ATRX Antibody (MA5-24609) in WBWestern blot analysis of extracts from A-549 cells, transfected with: control siRNA, target specific siRNA probe #1, target specific siRNA probe #2, using ATRX Monoclonal Antibody (CL0537) (Product # MA5-24609). Downregulation of antibody signal confirms target specificity. Remaining % intensity, relative control lane, is indicated. Anti-GAPDH monoclonal antibody was used as loading control.

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