CD62L (L-Selectin) Monoclonal Antibody (DREG-56 (DREG56)), APC, eBioscience

货号：17-0629-42

规格：100 Tests

市场价格：3090

产品类型：流式抗体

品牌：eBioscience

抗原：CD62L

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：DREG-56 (DREG56)

荧光染料：APC

类型:	一抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience
浓度：	5 µL/Test	用法：	5 µL (0.5 µg)/test（Flow）

产品详细信息Description: The DREG-56 monoclonal antibody reacts with human CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCAM-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.Applications Reported: The DREG-56 (DREG56) antibody has been reported for use in flow cytometric analysis.Applications Tested: The DREG-56 (DREG56) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.仅用于科研。不用于诊断过程

数据

CD62L (L-Selectin) Antibody (17-0629-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD4 FITC (Product # 11-0048-42) and Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (left) or Anti-Human CD62L (L-Selectin) APC (right). Cells in the lymphocyte gate were used for analysis.

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参考文献：

1. mBioType III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus InfectionIn Vivo.AuthorsDouam F,Soto Albrecht YE,Hrebikova G,Sadimin E,Davidson C,Kotenko SV,Ploss AYear2017SpeciesHumanDilution1:50 2. Cell researchBlocking the recruitment of naive CD4+T cells reverses immunosuppression in breast cancer."17-0629 was used in Flow cytometry/Cell sorting to demonstrate that blocking PITPNM3 recognition of CCL18 could be an attractive immunotherapy aproach for treating breast cancer."AuthorsSu S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song EYear2017SpeciesHuman 3. Nature communicationsSingle-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome."17-0629 was used in Flow cytometry/Cell sorting to demonstrate the tracking of and sense viral RNA at single-cell resolution within complex subsets of the human and murine immune system in different mouse models."AuthorsDouam F,Hrebikova G,Albrecht YE,Sellau J,Sharon Y,Ding Q,Ploss AYear2017SpeciesHumanDilution1:50 4. Human vaccines & immunotherapeuticsImmune responses induced by T-cell vaccination in patients with rheumatoid arthritis."17-0629 was used in Flow cytometry/Cell sorting to study how the T-cell immunotherapy regimen used resulted in the clinical improvement, which was achieved in 87% patients."AuthorsIvanova I,Seledtsova G,Mamaev S,Shishkov A,Seledtsov VYear2015SpeciesHuman 5. PLoS pathogensThe CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria."17-0629 was used in Flow cytometry/Cell sorting to study inflammatory monocyte subsets displaying increased mitochondrial activity and effector function during malaria."AuthorsAntonelli LR,Leoratti FM,Costa PA,Rocha BC,Diniz SQ,Tada MS,Pereira DB,Teixeira-Carvalho A,Golenbock DT,Gonçalves R,Gazzinelli RT

技术参数

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