Recombinant Human PDGF-AA
货号：100-13A-10,100-13A-100,100-13A-1000,100-13A-2,100-13A-250,100-13A-50,100-13A-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
市场价格：1560,9126,36565,640,15974,5475,23727
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).来源:E.coli别名:Platelet-Derived Growth Factor-AA, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)氨基酸序列 (monomer):SIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expectedED50for this effect is 1.0-3.0 ng/ml.Calculated Molecular Weight:28.5 kDaAccession Number:P04085Gene ID:5154交叉反应:Alpaca,Dog,Human,Lizard,Monkey,Mouse,Rat,Salamander,Zebra Fish原产地:USA仅用于科研，不能用于临床和诊断。 |
product.subtitle.recentcitations |
第一作者 | Hanson, M G |
标题 | Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. |
文献引用 | The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71 |
PubMed Id | 9736656 |
第一作者 | Back, S A |
标题 | Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. |
文献引用 | The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(16) pg6241-53 |
PubMed Id | 9698317 |
第一作者 | Fruttiger, M |
标题 | PDGF mediates a neuron-astrocyte interaction in the developing retina. |
文献引用 | Neuron; 17(6) pg1117-31 |
PubMed Id | 8982160 |
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