BIO-RAD MCA5944GT Mouse anti Human BRCA1 antibody, clone BR64,Mouse anti Human BRCA1 antibody, clone BR64-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA5944GT Mouse anti Human BRCA1 antibody, clone BR64,Mouse anti Human BRCA1 antibody, clone BR64

2024-10-22

Mouse anti Human BRCA1 antibody, clone BR64

货号：MCA5944GT

规格：50 µg

价格：4191

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：BRCA1

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：BR64

荧光染料：Purified

产品介绍
Mouse anti Human BRCA1 antibody, clone BR64recognizes an epitope within the100 amino acid N-Terminal (NT) regionof human BRCA1, otherwise known as breast cancer type 1 susceptibility protein, a tumor suppressor gene and major player in DNA damage repair, predominantly expressed in the nucleus during the S/G2 phase of the cell cycle.Along with BRCA2, BRCA1 is a high risk gene which is associated with hereditary breast and ovarian cancers, particularly at a younger age of diagnosis. Women carrying the BRCA1 mutation have a 50-95% chance of developing breast cancer in later life, but genetic screening and increased awareness of preventative surgery can reduce this risk significantly (Fordet al.1994). Deleterious BRCA1 mutations may also increase the risk of other cancers in both males and females including pancreatic cancer, although in males pancreatic and prostate cancer appear to be more strongly associated with BRCA2 gene mutations.BRCA1 is a key marker of triple-negative breast cancer/TNBC (ER-/PR-/HER2-), a high risk aggressive cancer which makes up about 15% of invasive breast cancers, and which lacks the benefit of specific therapy that targets the three major proteins ER/PR/HER2. Triple-negative tumors are predominantly basal-like, poorly differentiated and of higherhistological grade. Younger women have an increased rate of basal or BRCA related TNBC, compared with the higher proportion of apocrine, normal-like and rare subtypes of TNBC, seen in older women.During the characterization of clone BR64, it was determined that this antibody can be used in the identification of both native and denatured BRCA1, recognizing an epitope within amino acids 80-100 (Maul, G.G.et al.).Mouse anti Human BRCA1 antibody, clone BR64 is suitable for use in immunofluorescence, showing both a nuclear distribution and reaction with the centrosome.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.1% Sodium Azide (NaN3)
Immunogen	Purified protein corresponding to amino acids 1-100 within the N-Terminal region of Human BRCA1.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunoprecipitation	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Maul, G.G.et al.(1998) Nuclear redistribution of BRCA1 during viral infection.Cell Growth Differ. 9: 743-55

技术参数

产品应用 IP;WB

产品类型 Monoclonal Antibody

推荐用于 IP;WB

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BIO-RAD MCA5944GT Mouse anti Human BRCA1 antibody, clone BR64,Mouse anti Human BRCA1 antibody, clone BR64

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