Bio-Rad mouse anti human CLUSTERIN MCA2612,mouse anti human CLUSTERIN-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad mouse anti human CLUSTERIN MCA2612,mouse anti human CLUSTERIN

2024-10-22

mouse anti human CLUSTERIN

货号：MCA2612

规格：0.1 mg

价格：4616

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Clusterin

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：3R3/2

荧光染料：Purified

产品介绍
Mouse anti Human clusterin antibody, clone 3R3/2recognizes clusterin, an ubiquitously expressed protein of two 40 kDa chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas.Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
产品详情
Target Species	Human
Product Form	Purified Ig - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution	Borate buffered saline
Immunogen	Glomerular basement membrane from a post-mortem kidney.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Preservative Stabilisers	0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	Guaranteed until date of expiry. Please see product label.
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Kumita, J.R.et al.(2007) The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.J Mol Biol. 369 (1): 157-67.2.Shannan, B.et al.(2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control.J Mol Histol. 37 (5-7): 183-8.

技术参数

产品应用 Flow;IHC(F);WB;ELISA

产品类型单克隆抗体

推荐用于 Flow;IHC(F);WB;ELISA

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Bio-Rad mouse anti human CLUSTERIN MCA2612,mouse anti human CLUSTERIN

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