Bio-Rad mouse anti human iC3b (NEOantigen) MCA2607,mouse anti human iC3b (NEOantigen)-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad mouse anti human iC3b (NEOantigen) MCA2607,mouse anti human iC3b (NEOantigen)

2024-10-22

mouse anti human iC3b (NEOantigen)

货号：MCA2607

规格：0.1 mg

价格：4616

产品类型：流式抗体

品牌：Bio-Rad

抗原：iC3b

物种：人

宿主：小鼠

抗体亚型：IgG2b

克隆号：013III-1.16

荧光染料：Purified

产品介绍
Mouse anti Human iC3b (Neoantigen) antibody, clone 013III-1.16recognizes the ~42 kDa human inactive complement component 3b (iC3b) neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated.iC3b is thought to play a role in inducing tolerance (Sohnet al.2003), binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.
产品详情
Target Species	Human
Product Form	Purified Ig - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution	Borate buffered saline
Immunogen	Purified human iC3b
Approx. Protein Concentrations	Current, batch-specific concentration 1.045 mg/ml
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	Guaranteed until date of expiry. Please see product label.
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Description	Product Code	Applications	Pack Size
Mouse IgG1 Negative Control	MCA928	F	100 Tests/1ml
文献
1.Janssena, B.et al. (2007) Structural insights into the central complement component C3.Molecular Immunology. 44: 3-10.2.Bergmann-Leitner, E.S.et al.(2006) Complement 3d: from molecular adjuvant to target of immune escape mechanisms.Clin Immunol. 121 (2): 177-85.3.Sohn, J.H.et al.(2003) Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells.Nat Med. 9 (2): 206-12.

技术参数

产品应用 Flow;IHC(F);WB;ELISA;IHC(P)

产品类型单克隆抗体

推荐用于 Flow;IHC(F);WB;ELISA;IHC(P)

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Bio-Rad mouse anti human iC3b (NEOantigen) MCA2607,mouse anti human iC3b (NEOantigen)

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