Bio-Rad 人 CD221:Alexa Fluor 488,Mouse anti Human CD221:Alexa Fluor 488-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad 人 CD221:Alexa Fluor 488,Mouse anti Human CD221:Alexa Fluor 488

2024-10-22

Mouse anti Human CD221:Alexa Fluor 488

货号：MCA2344A488

规格：100 Tests/1ml

价格：3162

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD221

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：1H7

荧光染料：Alexa Fluor 488

产品介绍
Mouse anti Human CD221 antibody, clone 1H7recognizes human CD221, a ~155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by western blotting (Liet al.1993).CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signaling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221 (Liet al.1993).
产品详情
Target Species	Human
Product Form	Purified IgG conjugated to Alexa Fluor® 488 - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Acknowledgements	This product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or outlicensing@thermofisher.com
Buffer Solution	Phosphate buffered saline
Immunogen	Purified human placental IGF-I receptor.
Preservative Stabilisers	0.09%Sodium Azide
Max Ex/Em	Fluorophore	Excitation Max (nm)	Emission Max (nm)
Alexa Fluor®488	495	519
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Li, S.L.et al.(1993) Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor.Biochem Biophys Res Commun. 196 (1): 92-8.2.Beauvais, D.M. & Rapraeger, A.C. (2010) Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation.J Cell Sci. 123 (Pt 21): 3796-807.3.Krieger, C.C.et al.(2016) Thyrotropin/IGF-1 receptor crosstalk in Graves' ophthalmopathy pathogenesis.J Clin Endocrinol Metab. Apr 4: jc20161315. [Epub ahead of print]4.van Valen, F.et al.(2012) A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells.Sarcoma. 2012: 782970.

技术参数

产品应用 Flow

产品类型单克隆抗体

推荐用于 Flow

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Bio-Rad 人 CD221:Alexa Fluor 488,Mouse anti Human CD221:Alexa Fluor 488

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