Bio-Rad MCA1860T Mcm5抗体,mouse anti human Mcm5-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1860T Mcm5抗体,mouse anti human Mcm5

2024-10-22

mouse anti human Mcm5

货号：MCA1860T ,MCA1860

规格：20 µg,0.1 mg

价格：1037,2576

产品类型：流式抗体

品牌：Bio-Rad

抗原： Mcm5

物种：人

宿主：小鼠

抗体亚型：IgG2b, kappa

克隆号：CRCT5.1

荧光染料：Purified

产品介绍
Mouse anti Human Mcm5 antibody, clone CRCT5.1recognizes human Mcm-5 (minichromosome maintenance protein 5), also known as DNA replication licensing factor MCM5 or P1-CDC46. Mcm5 is a nuclear protein of ~95kDa with an important role in the control of DNA replication (Snyderet al.2005).Immunocytochemical assessment of Mcm5 expression may be of value in improving the accuracy of cervical smear testing for the detection of malignancy (Murphyet al.2004).
产品详情
Target Species	Human
Product Form	Purified IgG- liquid
Preparation	MCA1860: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant MCA1860T: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide
Carrier Free	Yes
Immunogen	Bacterially expressed human Mcm5.
Approx. Protein Concentrations	IgG concentration1.0 mg/ml
Fusion Partners	Spleen cells from immunised CBI/CFI mice were fused with cells of the mouse SP2 myeloma cell line.
Regulatory	For research purposes only
Guarantee	Guaranteed for 12 months from the date of despatch .
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Paraffin1	√	1/25Pack Size: 0.1 mg1/50Pack Size: 20 µg	1/100Pack Size: 0.1 mg1/ 1000Pack Size: 20 µg
Western Blotting	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewedpublications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. Histology Positive Control TissueTonsil / Cervical Carcinoma
数据
Staining of formalin fixed, paraffin embedded human tonsil with Mouse anti Human MCM5 (MCA1860).
文献
1. (2011) Human Protein Atlas: CAB000101Human Protein Atlas: CAB0001012. Dart, D.A.et al.(2004) Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase.J Biol Chem. 279: 16433-40.3. Adams, K.E.et al.(2006) Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex.Oncogene. 25: 3894–904.4. Gakiopoulou, H.et al.(2007) Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications.British Journal of Cancer 97: 1124–34.5. Guida, T.et al.(2005) Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma.J Clin Endocrinol Metab. 90: 4703-9.6. Polo, S.E.et al.(2010) Clinical significance and prognostic value of chromatin assembly factor-1 overexpression in human solid tumours.Histopathology. 57: 716-24.

技术参数

产品应用 IHC(P) *; WB

产品类型 Monoclonal Antibody

推荐用于 IHC(P) *; WB

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Bio-Rad MCA1860T Mcm5抗体,mouse anti human Mcm5

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