Bio-Rad MCA1283F CD88 抗体,mouse anti human CD88:FITC-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1283F CD88 抗体,mouse anti human CD88:FITC

2024-10-22

mouse anti human CD88:FITC

货号：MCA1283F

规格：0.1 mg

价格：2576

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD88

物种：人

宿主：小鼠

抗体亚型：IgG2a

克隆号：S5/1

荧光染料：FITC

产品介绍
Mouse anti Human CD88 antibody, clone S5/1recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21).Clone S5/1 has been shown to inhibit the binding of C5a to its receptor.
产品详情
Target Species	Human
Species Cross-Reactivity	Target Species	Cross Reactivity
Rabbit	√
Mustelid	Expected from Sequence
Bovine	√
Ferret	√
Mink	√
N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin
Immunogen	C5aR - peptide: Met1 - Asn31.
Approx. Protein Concentrations	IgG concentration 0.1 mg/ml
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the X63-Ag8 myeloma cell line.
Max Ex/Em	Fluorophore	Excitation Max (nm)	Emission Max (nm)
FITC	490	525
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	Neat
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewedpublications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Flow Cytometry Use 10ul of the suggested working dilution to label 106cells or 100ul whole blood
数据
Figure A. FITC conjugated mouse anti human CD11b (MCA551F) and Alexa647® conjugated Mouse IgG1 isotype control (MCA928A647). Figure B. FITC conjugated mouse anti human CD11b (MCA551F) and Alexa647® conjugated mouse anti human CD13 (MCA1270A647). All experiments performed on red cell lysed Human peripheral blood gated on all mononuclear cells in the presence of Human SeroBlock (BUF070A).
同型
Description	Product Code	Applications	Pack Size
Mouse IgG2a Negative Control:FITC	MCA928F	F	100 Tests
相关产品
Description	Product Code	Applications	Pack Size
Human Seroblock	BUF070A	F	50 Test
Human Seroblock	BUF070B	F	200 Test
文献
1. Schreiber, A.et al.(2009) C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis.J Am Soc Nephrol. 20: 289-98.2. Eglite, S.et al.(2000) Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils.J Immunol. 165: 2183-9.3. Conroy, A.et al.(2009) C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.PLoS One. 4: e4953.4. Kraft, K.et al.(2001) Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.J Biol Chem. 276: 34408-18.5. Fukuoka, Y.et al.(2008) Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5.J Immunol. 180: 6307-16.6. Bettoni, S.et al.(2017) Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis.J Immunol. 199 (3): 1021-40.7. Huang, L.et al.(2005) Discovery of human antibodies against the C5aR target using phage display technology.J Mol Recognit.18: 327-33.8. Tseng CWet al.(2015) Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin andStaphylococcus aureusSkin Infection.PLoS Pathog. 11 (11): e1005292.

技术参数

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Bio-Rad MCA1283F CD88 抗体,mouse anti human CD88:FITC

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