Human anti golimumab (drug/target complex), clone AbD25705 ,Human anti golimumab (drug/target complex), clone AbD25705-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human anti golimumab (drug/target complex), clone AbD25705 ,Human anti golimumab (drug/target complex), clone AbD25705

2024-10-22

Human anti golimumab (drug/target complex), clone AbD25705

货号：HCA274

规格：0.1 mg

价格：4446

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：golimumab

物种：其它

宿主：人

抗体亚型：IgG1

克隆号：AbD25705

荧光染料：Purified

产品介绍
Human anti golimumab (drug/target complex), clone AbD25705is an affinity matured recombinant antibody in monovalent Fab format that specifically recognizes golimumab when in complex with its target, tumor necrosis factor alpha (TNFα). Clone AbD25705 does not recognize unbound golimumab nor free TNFα. The antibody can be used in a pharmacokinetic (PK) antigen capture format assay to measure golimumab that has been captured via immobilized human TNFα. It is ideal for bioanalytical assays to measure the level of drug or biosimilar in complex with the TNFα target.Golimumab, marketed under the brand name Simponi®, is a recombinant human IgG1/kappa monoclonal antibody approved for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. This therapeutic antibody, directed against TNFα, acts by blocking the binding of TNFα to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.
产品详情
Product Form	A monovalent human recombinant Fab (lambda light chain) selected from the HuCAL® phage display library, expressed inE. coli.The antibody is tagged with a DYKDDDDK tag and a HIS-tag (HHHHHH) at the C-terminus of the antibody heavy chain. This antibody is supplied as a liquid.
Preparation	Metal chelate affinity chromatography
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Immunogen	Golimumab/TNFα complex
Affinity	The monovalent intrinsic affinity of AbD25705 was measured as KD= 6 nM by real time, label free molecular interaction analysis on immobilized golimumab in complex with human TNFα.
Approx. Protein ConcePurityntrations	IgG concentration 0.5 mg/ml
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.His-tag is a registered trademark of EMD Biosciences.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	1/50	1/800
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
产品推荐
Description	Product Code	Applications	Pack Size
Hispec Assay Diluent	BUF049A	E	50ml

技术参数

产品应用 elisa

产品类型单克隆抗体

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Human anti golimumab (drug/target complex), clone AbD25705 ,Human anti golimumab (drug/target complex), clone AbD25705

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