Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) ,Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) antibod-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) ,Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) antibod

2024-10-22

Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) antibody

货号：AHP2700

规格：50 µl

价格：3341

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425)

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) antibodyrecognizes mothers against decapentaplegic homolog 2 (SMAD2), when phosphorylated at serine 465 and serine 467 and mothers against decapentaplegic homolog 3 (SMAD3) when phosphorylated at serine 423 and serine 425. The SMAD protein family mediates transforming growth factor-beta (TGF-β) signaling from the membrane to the nucleus (Attisano, L. & Wrana, J.L. 2002). SMAD2 is phosphorylated on serine 465 and serine 467 by TGF beta type I receptor (TbetaRI). This phosphorylation is essential for SMAD2’s binding to SMAD4 and for the orchestration of TGF beta signaling (Abdollah, S. et al. 1997). The antibody also recognizes SMAD3 phosphorylated on Ser423 and Ser425 by homology.The TGF beta signaling pathway is involved in many cellular processes including cell growth, differentiation and proliferation. The pathway is deregulated in various diseases, including cancer.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antiserum to SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02% Sodium Azide50% Glycerol
Immunogen	Phospho specific-peptide corresponding to residues surrounding serine 465/467 of human SMAD2 and serine 423/425 of human SMAD3
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Store at -20℃Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	1/500	1/2000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
文献
1.Ramsauer, K.et al.(2002) p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation.Proc Natl Acad Sci U S A. 99 (20): 12859-64.

技术参数

产品应用 wb

产品类型 Polyclonal Antibody

推荐用于 wb

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Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) ,Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) antibod

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