Bio-Rad Delta-Like Protein 1抗体 AHP2251,Goat anti Delta-Like Protein 1-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad Delta-Like Protein 1抗体 AHP2251,Goat anti Delta-Like Protein 1

2024-10-22

Goat anti Delta-Like Protein 1

货号：AHP2251

规格：0.1 mg

价格：4148

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Delta-Like Protein 1

物种：人

宿主：山羊

抗体亚型：IgG

荧光染料：Purified

产品介绍
Goat anti Human Delta-like protein 1 antibodyrecognizes Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signalling pathway, activated through the binding of specific ligands to the Notch receptors Notch 1-4.The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression.Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation.DLL1 is widely expressed, and acts as a mediator of cell fate decisions during haematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signalling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB).
产品详情
Target Species	Human
Species Cross-Reactivity	Target Species Cross Reactivity
	Mouse √
	Rat √
	N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG - liquid
AntiserumPreparation	Antiserum to human DLL1 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution	TRIS buffered saline
Preservative Stabilisers	0.02% Sodium Azide (NaN₃)0.5% Bovine Serum Albumin
Immunogen	Synthetic peptide sequence C-ATQRHLTVGEEWSQD from the internal region of DLL1 (NP_005609.3).
Approx. Protein Concentrations	IgG concentration 0.5mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/16,000
Western Blotting	√	0.3	1.0ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Western Blotting AHP2251detects a band of approximately 75kDa in mouse and rat heart cell lysates.
二抗相关产品
Description	Product Code	Applications	Pack Size
Rabbit anti Goat IgG (Fc):FITC	STAR122F	F	1 mg
Rabbit anti Goat IgG (Fc):HRP	STAR122P	C E WB	1 mg

技术参数

产品应用 E; WB

产品类型 Polyclonal Antibody

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Bio-Rad Delta-Like Protein 1抗体 AHP2251,Goat anti Delta-Like Protein 1

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