Bio-Rad AHP1365 PDCD4,Rabbit anti Human PDCD4 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1365 PDCD4,Rabbit anti Human PDCD4 antibody

2024-10-22

Rabbit anti Human PDCD4 antibody

货号：AHP1365

规格：50 µg

价格：3341

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：PDCD4

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human PDCD4 antibodyrecognizes the carboxy-terminal region of programmed cell death 4 (Pdcd4), a novel tumour suppressor. Pdcd4 interacts with the RNA helicase eIF4A and the scaffolding protein eIF4G, two components of the translation initiation complex, and thus inhibits protein synthesis. Pdcd4 has also been shown to inhibit transcription factor activator protein-1 (AP-1), which regulates several events required for cell invasion, including expression of matrix metalloproteinases and cell motility.Pdcd4 localizes to the nucleus in proliferating cells, and its expression is modulated by cytokines in natural killer and T cells. Pdcd4 expression is down regulated with tumour progression in carcinomas of the lung, colon, prostate and breast.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to Pdcd4 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN₃)
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Immunogen	Synthetic peptide corresponding to amino acids near the carboxy terminal of human Pdcd4.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/10000	1/50000
Immunohistology - Paraffin¹	√	1/100	1/300
Western Blotting	√	1/1000	1/10000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. ¹This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Histology Positive Control Tissue Mouse colon. Western Blotting AHP1365 detects a band of approximately 52kDa.
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文献
1. Palamarchuk, A.et al.(2005) Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.Cancer Res. 65 (24): 11282-6.

技术参数

产品应用 ELISA;IHC(P)*;WB

产品类型 Polyclonal Antibody

推荐用于 ELISA;IHC(P)*;WB

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Bio-Rad AHP1365 PDCD4,Rabbit anti Human PDCD4 antibody

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