Rabbit anti Human CD253 antibody AHP1215 bio-rad,Rabbit anti Human CD253 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Human CD253 antibody AHP1215 bio-rad,Rabbit anti Human CD253 antibody

2024-10-22

Rabbit anti Human CD253 antibody

货号：AHP1215

规格：0.1 mg

价格：4021

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：CD253

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human CD253 antibodyrecognizes human tumor necrosis factor ligand superfamily member 10 otherwise known as TRAIL, CD253 or Apo2L. CD253 is a 281 amino acid type II transmembrane glycoprotein and member of the tumour necrosis factor superfamily, which induces apoptosis in tumour and transformed cells, but not normal cells.Activation of apoptosis by CD253 occurs through binding to the death-signaling receptors DR4 (TRAILR1) and DR5 (TRAILR2), leading to formation of the death-inducing signaling complex (DISC) and the triggering of a proteolytic caspase cascade. There are however decoy receptors known as DcR1 (TRAILR3) and DcR2 (TRAILR4) which competitively bind to CD253 and are unable to initiate apoptosis.CD253 also plays a role in immune surveillance, acting as a mediator of monocyte, NK cell, dendritic cell and T cell anti-tumour and anti-viral cytotoxicity.
产品详情
Target Species	Human
Product Form	Purified IgG - lyophilized
Reconstitution	Reconstitute with 0.1ml distilled waterCare should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.N.B. For functional studies do not add sodium azide
Antiserum Preparation	Antisera to human CD253 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography against immobilized antigen.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	None present
Immunogen	Recombinant human CD253 (PHP125)
Approx. Protein Concentrations	IgG concentration 1.0mg/ml after reconstitution.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Prior to reconstitution store at -20°C.After reconstitution store at -20°C.This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	0.1	0.2ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
文献
1.Koyama, S.et al.(2002) Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor.J Cancer Res Clin Oncol. 128 (2): 73-9.2.Plasilova, M.et al.(2002) TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors.Leukemia. 16 (1): 67-73.3.Graf, D.et al.(2003) Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms.Arch Biochem Biophys. 415 (1): 34-42.4.Chi, H.C.et al.(2012) Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL.Cell Death Differ. 19 (11): 1802-14.

技术参数

产品应用 elisa；wb

产品类型 Polyclonal Antibody

推荐用于 elisa；wb

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Rabbit anti Human CD253 antibody AHP1215 bio-rad,Rabbit anti Human CD253 antibody

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