Bio-Rad AHP1173 IL-23 ,Rabbit anti Human IL-23 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1173 IL-23 ,Rabbit anti Human IL-23 antibody

2024-10-22

Rabbit anti Human IL-23 antibody

货号：AHP1173

规格：0.1 mg

价格：4573

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：IL-23

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human IL-23 antibodyrecognizes the C-terminal (CT) domain of human interleukin-23 (IL-23), a ~21 kDa heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to human IL-23 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02%Sodium Azide (NaN₃)
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Immunogen	A 14 amino acid peptide from near the carboxy-terminus of human IL-23.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Frozen	√		10ug/ml
Western Blotting	√	1	2ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Histology Positive Control Tissue Raji cells. Western Blotting AHP1173 detects a band of approximately 24kDa in Raji cell lysates
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Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E;WB	1 mg
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数据
Western blot analysis of whole cell lysate form Raji, human Burkitt's lymphoma derived cells probed with Rabbit anti Human Interleukin-23 (AHP1173) in the absence (A) or presence (B) of blocking peptide.
文献
1. Kikly, K.et al.(2006) The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.Curr Opin Immunol. 18 (6): 670-5.2. Hu, W.et al.(2006) Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.Arch Neurol. 63 (6): 858-64.3. Langrish, C.L.et al.(2004) IL-12 and IL-23: master regulators of innate and adaptive immunity.Immunol Rev. 202: 96-105.4. Hunter, C.A. (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.Nat Rev Immunol. 5 (7): 521-31.

技术参数

产品应用 IHC(F);WB

产品类型 Polyclonal Antibody

推荐用于 IHC(F);WB

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Bio-Rad AHP1173 IL-23 ,Rabbit anti Human IL-23 antibody

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