Bio-Rad IRAK4 抗体 AHP1662,Rabbit anti Human IRAK4 (C-Terminal)-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad IRAK4 抗体 AHP1662,Rabbit anti Human IRAK4 (C-Terminal)

2024-10-22

Rabbit anti Human IRAK4 (C-Terminal)

货号：AHP1662

规格：0.1 mg

价格：4990

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：IRAK4

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human IRAK4 (C-Terminal) antibodydetects an epitope within the C-Terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 is a 460 amino acid ~50 kDa, cytoplasmic protein and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.Two isoforms of IRAK4 produced by alternative splicing are predicted, Rabbit anti Human IRAK4 (C-Terminal) antibody is expected to recognize both isoforms which differ by an N-terminal deletion.Mutations in the IRAK4 gene can lead to the development of Recurrent isolated invasive pneumococcal disease 1 (IPD1) characterized by multiple episodes of IPD occurring at least one month apart (Kuet al.2007). IRAK4 mutation can also lead to the development of IRAK4 deficiency (IRAK4D) demonstrating extracellular pyogenic bacterial and fungal infections in otherwize healthy children (Picardet al.2003).
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
AntiserumPreparation	Antiserum to IRAK4 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02% Sodium Azide (NaN₃)
Immunogen	A peptide corresponding to amino acids at the carboxy terminus of human IRAK4.
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Frozen	√		10ug/ml
Western Blotting	√	1	2ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Western Blotting AHP1662 detects a band of approximately 50kDa in HeLa cell lysates.
可用二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E WB	1 mg
Goat anti Rabbit IgG (Fc):FITC	STAR121F	F	1 mg
Goat anti Rabbit IgG (Fc):HRP	STAR121P	E WB	1 mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C E WB	1 mg
Sheep anti Rabbit IgG:FITC	STAR34B	C F	1 mg
Sheep anti Rabbit IgG:RPE	STAR35A	F	1 ml
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Description	Product Code	Applications	Pack Size
TidyBlot Western Blot Detection Reagent:HRP	STAR209P	WB*	0.5 ml
文献
1.Suzuki, N.et al. (2002) IRAK-4 as the central TIR signaling mediator in innate immunity.Trends Immunol. 10: 503-506.2.Suzuki, N. and Saito, T. (2006) IRAK-4- a shared NF-kappaB activator in innate and acquired immunity.Trends Immunol. 27: 566-572.

技术参数

产品应用 C ;WB

产品类型 Polyclonal Antibody

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Bio-Rad IRAK4 抗体 AHP1662,Rabbit anti Human IRAK4 (C-Terminal)

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