Bio-Rad 4890-0004P Haptoglobin,Sheep anti Human Haptoglobin:HRP

2024-10-22

Sheep anti Human Haptoglobin:HRP

货号:4890-0004P

规格:1 ml

价格:2465

产品类型:免疫组化一抗

品牌:Bio-Rad

抗原:Haptoglobin

物种:人

宿主:Sheep

抗体亚型:IgG

荧光染料:HRP

产品介绍
Sheep anti Human Haptoglobin antibodydetects haptoglobin, also known as Hp, an acute phase plasma glycoprotein synthesized by the liver in response to infection or inflammation. Haptoglobin binds haemoglobin released by erythrocytes with high affinity, and functions to block the oxidative activity of haemoglobin and prevent renal damage. The haptoglobin-haemoglobin complex is rapidly removed from the circulation by monocytes and macrophages, via the receptor CD163.The haptoglobin genotype is an independent risk factor for cardiovascular disease (Levyet al. 2002).
产品详情

Target Species

Human

Product Form

Purified IgG - liquid

Antiserum Preparation

Antisera to Haptoglobin were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Buffer Solution

Phosphate buffered saline

Preservative Stabilisers

0.01%Thiomersal

Approx. Protein Concentrations

IgG concentration 1.0mg/ml

Immunogen

Native, purified human haptoglobin from serum.

Regulatory

For research purposes only

Guarantee

12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用

Application Name

Verified

Min Dilution

Max Dilution

ELISA

1/100

1/1000

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
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数据

Human Haptoglobin detected with Sheep anti Human Haptoglobin: HRP (4890-0004P).
文献

1. Carter, K. & Worwood, M. (2007) Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases.Int J Lab Hematol. 29 (2): 92-110.2. Guetta, J.et al. (2007) Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin.Atherosclerosis. 191: 48-53.3. Araki, H.et al.(2015) Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients.Cancer Immunol Immunother. 64 (12): 1565-73.4. Soejima, M.et al.(2014) Genetic factors associated with serum haptoglobin level in a Japanese population.Clin Chim Acta. 433: 54-7.

技术参数

产品应用 ELISA

产品类型 Polyclonal Antibody

推荐用于 ELISA

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