Recombinant Human PDGF-BB
货号：100-14B-10,100-14B-100,100-14B-1000,100-14B-2,100-14B-250,100-14B-50,100-14B-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1560,9126,36565,640,15974,5475,23727
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of twoβ chains (218 total amino acids). .来源:E.coli别名:Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)氨基酸序列 (monomer):SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells.The expectedED50for this effect is 1.0-3.0 ng/ml.Calculated Molecular Weight:24.3 kDaAccession Number:P01127Gene ID:5155交叉反应:Cow,Dog,Guinea Pig,Hamster,Human,Human + Mouse,Monkey,Mouse,Pig,Rat原产地:USA仅用于科研，不能用于临床和诊断。 |
product.subtitle.recentcitations |
第一作者 | Hanson, M G |
标题 | Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. |
文献引用 | The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71 |
PubMed Id | 9736656 |
第一作者 | Asano, T |
标题 | GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo. |
文献引用 | European journal of biochemistry; 251(1-2) pg314-9 |
PubMed Id | 9492299 |
第一作者 | Fruttiger, M |
标题 | PDGF mediates a neuron-astrocyte interaction in the developing retina. |
文献引用 | Neuron; 17(6) pg1117-31 |
PubMed Id | 8982160 |
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