Bio-Rad 2222-6604 C3c,Sheep anti Human C3c-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad 2222-6604 C3c,Sheep anti Human C3c

2024-10-22

Sheep anti Human C3c

货号：2222-6604

规格：1 ml

价格：2023

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：C3c

物种：人

宿主：Sheep

抗体亚型：IgG

荧光染料：Purified

产品介绍
Sheep anti Human C3c antibodydetects human complement 3c, a polypeptide fragment which is present in C3. C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection.This antbody shows minimal reactivity with related serum proteins.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide (NaN₃)
Approx. Protein Concentrations	IgG concentration 5.0 mg/ml
Immunogen	Native human C3c purified from serum.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/400
Immunohistology - Frozen	√	1/50
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
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Donkey anti Sheep/Goat IgG:DyLight®488	STAR88D488GA	F;IF	0.1 mg
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数据
Native Human C3c detected using Sheep anti Human C3c:FITC (2222-6604F).
文献
1. Janssen, B.J.et al.(2005) Structures of complement component C3 provide insights into the function and evolution of immunity.Nature. 437 (7058): 505-11.2. Lewis, L.A.et al.(2019) Effect of a C1s Inhibitor on the Efficacy of Anti-Capsular Antibodies againstNeisseria meningitidisandStreptococcus pneumoniae.Immunohorizons. 3 (11): 519-30.

技术参数

产品应用 IHC(F);ELISA

产品类型 Polyclonal Antibody

推荐用于 IHC(F);ELISA

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Bio-Rad 2222-6604 C3c,Sheep anti Human C3c

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