Recombinant Human GPR15L
货号：300-71-100,300-71-1000,300-71-25,300-71-250,300-71-5,300-71-500
规格：100ug,1mg,25ug,250ug,5ug,500ug
价格：6379,25574,1418,11161,582,16588
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：GPR15L is a newly identified ligand for GPR15, a member of the G protein-coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15-expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. While maintaining similar expression patterns and intramolecular disulfide cysteine bridges found in members of the CC chemokine family, GPR15L differs from classic CC and CXC chemokines, whose active sites are found on the N-terminus, in that it relies on its C-terminus for receptor interaction. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth. PeproTech’sE.coli-derived Recombinant Human GPR15L consists of 57 amino acid residues and has a calculated molecular weight of 6.5 kDa.来源:E.coli别名:Antimicrobial peptide-57, AP-57, Colon-derived SUSD2 binding factor, CSBF, UNQ1833/PRO3446氨基酸序列:KRRPAKAWSG RRTRLCCHRV PSPNSTNLKG HHVRLCKPCK LEPEPRLWVV PGALPQV纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to chemoattract human PBMC's in a transwell-based migration assay.Calculated Molecular Weight:6.5 kDaAccession Number:Q6UWK7Gene ID:387695原产地:USA仅用于科研，不能用于临床和诊断。 |
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