PeproTech AF-100-11R3 细胞因子人 IGF-I LR3,Animal-Free Recombinant Human IGF-I LR3-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

PeproTech AF-100-11R3 细胞因子人 IGF-I LR3,Animal-Free Recombinant Human IGF-I LR3

2024-10-23

Animal-Free Recombinant Human IGF-I LR3

货号：AF-100-11R3-1000,AF-100-11R3-200

规格：1mg,200ug

价格：1731,767

产品类型：细胞生物学

品牌：PeproTech

产品描述：The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissuein vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potencyin vitro, IGF-I LR3 has an increased half-life and a binding aversion to native proteins within the body that make it ideal for both research and large-scale culturing. Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.Manufactured using all Animal-Free reagents.来源：E.coli别名:Long R3 IGF-I, Insulin-like Growth Factor-I, Somatamedin C, IGF-IA氨基酸序列：MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA纯度：≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性：TheED₅₀was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵units/mg.Calculated Molecular Weight:9.1 kDaAccession Number:P05019Gene ID:3479交叉反应：Mouse

技术参数

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PeproTech AF-100-11R3 细胞因子人 IGF-I LR3,Animal-Free Recombinant Human IGF-I LR3