Animal-Free Recombinant Human GDF-5 (BMP-14/CDMP-1)
货号：AF-120-01-10,AF-120-01-100,AF-120-01-50,AF-120-01-250,AF-120-01-500,AF-120-01-1000
规格：10µg,100µg,50µg,250µg,500µg,1mg
价格：795,4020,1826,6785,10081,15545
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：AF-120-01产品描述：GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human GDF-5 (BMP-14/CDMP-1) is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.Manufactured using all Animal-Free reagents.Source:E.coliSynonyms:Growth/Differentiation Factor-5, Bone Morphogenetic Protein-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)AA Sequence (monomer):APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCRPurity:≥ 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expectedED50for this effect is 1.0-2.0 µg /ml.Calculated Molecular Weight:27 kDaAccession Number:P43026Gene ID:8200Country Of Origin:USANot for human use. |
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