SSEA1 Monoclonal Antibody (VIMC6), Pacific Blue

货号：MHCD1528

规格：0.5 mL

价格：5474

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgM

克隆号：VIMC6

荧光染料：Pacific Blue

类型:	单抗	同型对照：
浓度：		用法：	Assay-Dependent(Flow)

产品详细信息Our Pacific Blue™ dye is optimally excited by the violet laser and conjugates of this dye are strongly fluorescent even at neutral pH. Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, facilitating two-color analysis.靶标信息CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.

数据

SSEA1 Antibody (MHCD1528) in FlowHuman peripheral blood granulocytes (black line) and lymphocytes (gray line) were stained with Pacific Blue™-conjugated anti-human CD15 monoclonal antibody (Product # MHCD1528).

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参考文献：

1.The Journal of experimental medicineIL1RAP potentiates multiple oncogenic signaling pathways in AML."MHCD1528 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo."2.Cancer cellDirect Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia."MHCD1528 was used in Flow cytometry/Cell sorting to identify BTSA1, a pharmacologically optimised BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis."3.Nature chemical biologyNew IDH1 mutant inhibitors for treatment of acute myeloid leukemia."MHCD1528 was used in flow cytometry to assess the effects of allosteric inhibitors on different mutant forms of isocitrate dehydrogenase 1 in leukemia"

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