c-Kit Polyclonal Antibody

货号：PA5-16770

规格：500 µL

价格：5697

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	1:100(IHC (P))

产品详细信息PA5-16770 targets CD117 in IHC (P) applications and shows reactivity with Canine, Rat and Human samples.The PA5-16770 immunogen is a synthetic peptide from the cytoplasmic domain of human CD117 / c-kit protein.靶标信息c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

数据

c-Kit Antibody (PA5-16770) in IHCFormalin-fixed, paraffin-embedded human stroma tumor stained with CD117/c-kit antibody using peroxidase-conjugate and AEC. Note staining of tumor cells.

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参考文献：

1.Brain sciencesMast Cells in the Auditory Periphery of Rodents."PA5-16770 was used in Western Blot, Immunohistochemistry (Paraffin) to show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis."AuthorsSzczepek AJ,Dudnik T,Karayay B,Sergeeva V,Olze H,Smorodchenko A2.Coronary artery diseaseWharton's jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction."PA5-16770 was used in immunohistochemistry to use a miniswine model of acute myocardial infarction to study the therapeutic effects of Wharton's jelly-derived mesenchymal stem cells on cardiac repair and performance"AuthorsZhang W,Liu XC,Yang L,Zhu DL,Zhang YD,Chen Y,Zhang HY3.Brain sciencesMast Cells in the Auditory Periphery of Rodents."PA5-16770 was used in Western Blot, Immunohistochemistry (Paraffin) to show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis."AuthorsSzczepek AJ,Dudnik T,Karayay B,Sergeeva V,Olze H,Smorodchenko A4.Neuro-oncologyPhase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)."PA5-16770 was used in immunohistochemistry - paraffin section to run phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma"AuthorsLassman AB,Pugh SL,Gilbert MR,Aldape KD,Geinoz S,Beumer JH,Christner SM,Komaki R,DeAngelis LM,Gaur R,Youssef E,Wagner H,Won M,Mehta MP5.The Journal of pharmacology and experimental therapeuticsChanges in the Neuronal Control of the Urinary Bladder in a Model of Radiation Cystitis."PA5-16770 was used in Immunohistochemistry to propose bladder irradiation affects several levels of neuronal control of the urinary bladder."AuthorsGiglio D,Podmolíková L,Tobin G

技术参数

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