CD11b Monoclonal Antibody (198)
货号:MA5-28264
规格:100 µg
价格:4270
产品类型:流式抗体
品牌:Thermo Fisher
物种:兔
宿主:小鼠
抗体亚型:IgG1
克隆号: 198
荧光染料:其它
类型: | 单抗 | 同型对照: | |
浓度: | 1 mg/mL | 用法: | Assay-dependent (IHC (F)); 1:100-1:200 (Flow); Assay-dependent(IP) |
产品详细信息
Mouse anti Rabbit CD11b antibody, clone 198 recognizes the rabbit CD11b cell surface glycoprotein, also known as the integrin alpha M chain and MAC-1.
靶标信息
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
数据 |
CD11b Antibody (MA5-28264) in Flow Flow cytometry of CD11b in peripheral blood mononuclear cells. Samples were incubated with CD11b monoclonal antibody (Product # MA5-28264). Image details are as follows: A) Representative flow cytometry dot plots are shown for each double staining, they illustrate the data obtained at day 17 post-infection for the PBMC of rabbits MR17/1 and IR17/1. B) The percentage of BrdU positive cells amongst the indicated cellular subset was determined and compared between AlHV-1 infected (left column: bold lines; middle and right columns: hatched bars) and mock infected (left column: dotted lines; middle and right columns: open bars) groups. Image referenced from: PLoS ONE 3: e1627. |
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