CD14 Monoclonal Antibody (TuK4)

货号：MHCD1400

规格：0.5 mL

价格：2400

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG2a

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	Assay-Dependent(Flow)

靶标信息CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.

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参考文献：

1.VirusesCellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice."MHCD1400 was used in Flow cytometry/Cell sorting to provide the visualization and direct measurement of the early steps of HIV reservoir expansion within anatomically intact lymphoid tissues soon after EFdA cessation and suggest a strategy to enhance therapeutic approaches aimed at eliminating the HIV reservoir."2.Cytometry. Part A : the journal of the International Society for Analytical CytologyOptimization of mass cytometry sample cryopreservation after staining."MHCD1400 was used in flow cytometry to demonstrate that freezing already-stained samples suspended in 10% DMSO in FBS is practical and efficient way to preserve already-stained samples for mass cytometry assessment"3.Clinical immunology (Orlando, Fla.)Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a."MHCD1400 was used in flow cytometry to determine the S. Typhi, S. Paratyphi A, and S. Paratyphi B cross-reactive CD4 positive T cell responses elicited by immunization with Ty21a"4.PloS oneVariation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1."MHCD1400 was used in flow cytometry to elucidate regulation of γ-globin expression in F-cells."5.Journal of immunology (Baltimore, Md. : 1950)Restoration of CD4+ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype."MHCD1400 was used in flow cytometry to study the dynamics of Ag-specific CD4(+) T cells during antiretroviral therapy."

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