GATA2 Recombinant Polyclonal Antibody (11HCLC)

货号：710242

规格：100 µg

价格：4809

产品类型：抗体和染料

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG

克隆号：11HCLC

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.5 mg/mL	用法：	2-5 µg/mL (WB)；1-3 µg/mL(ICC/IF)

产品详细信息This antibody is predicted to react with equine, non-human primate, mouse, rabbit and rat based on sequence homology.Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.靶标信息GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.

数据

GATA2 Antibody (710242) in ICC/IFImmunofluorescent analysis of GATA2 in U2OS cells using a GATA2 Recombinant Rabbit Polyclonal Antibody (Product # 710242) followed by detection using an Alexa Fluor 488-conjugated Goat anti-Rabbit secondary antibody (green) (Image A). Nuclei were stained using DAPI (Image B) and actin stained with Alexa Fluor 594 phalloidin (red) (image C). Image D is a composite image showing nuclear localization of GATA2.

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参考文献：

1.EMBO molecular medicine3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB."710242 was used in Western Blotting to suggest that 3,4-DC is a novel caloric restriction mimetic (CRM) with a previously unrecognized mode of action."AuthorsChen G,Xie W,Nah J,Sauvat A,Liu P,Pietrocola F,Sica V,Carmona-Gutierrez D,Zimmermann A,Pendl T,Tadic J,Bergmann M,Hofer SJ,Domuz L,Lachkar S,Markaki M,Tavernarakis N,Sadoshima J,Madeo F,Kepp O,Kroemer G2.Nature communicationsThe flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species."710242 was used in Western Blotting to identify the flavonoid, 4,4'-dimethoxychalcone, as a natural compound with anti-ageing properties."

技术参数

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