Recombinant Human ICAM-2 Fc
货号：150-22-500,150-22-10,150-22-250,150-22-50,150-22-100,150-22-1000
规格：500 ug,10 ug,250 ug,50 ug,100 ug,1mg
价格：8332,585,5608,1425,3202,12850
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Intracellular adhesion molecule‐2 (ICAM‐2), also known as CD102, is a member of the Ig superfamily of calcium‐ independent transmembrane glycoproteins. ICAM‐2 is a ligand for theβ2‐integrins, lymphocyte function‐ associated antigen‐1 (LFA‐1) and Mac‐1. Constitutively expressed on all vascular endothelial cells and at endothelial cell junctions, it is also expressed at low levels on most leukocytes. As a cell surface adhesion molecule, it is involved in leukocyte recruitment and mediates leukocyte binding. Through interaction with LFA‐1, ICAM‐2 activates the PI3K/AKT pathway which leads to inhibition of TNF‐αand Fas‐mediated apoptosis. ICAM‐2 is highly expressed in lymphomas and it is postulated to be involved in lymphocyte recirculation and trafficking. T cell crawling and diapedesis across the blood‐brain barrier has been shown to be regulated by ICAM‐2 via ligation of LFA‐1 as well as neutrophil crawling and IL‐1ß‐stimulated extravasation through ligation of Mac‐1. ICAM‐2 has been shown to suppress neuroblastoma cell motility by binding with the cytoskeletal linker proteinα‐actinin which, in turn, regulates metastasis. Additionally, it has been found to enhance the immune response in colon carcinoma cells and induce an antitumor immune response in pancreatic carcinogenesis. PeproTech's CHO‐ derived Recombinant Human ICAM‐2 Fc is a glycosylated, disulfide‐linked homodimer of 435 amino‐acid‐residues whose monomer consists of the 202‐amino‐acid extracellular portion of ICAM‐2 fused to the 231‐amino‐acid length Fc portion of human IgG by two glycine residues.The calculated molecular weight of monomeric CHO cell‐ derived Recombinant Human ICAM‐2 Fc is 48.5 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 70‐80 kDa by SDS‐PAGE analysis under reducing conditions.来源:CHO cells别名:Intracellular adhesion molecule 2, CD102氨基酸序列:SDEKVFEVHV RPKKLAVEPK GSLEVNCSTT CNQPEVGGLE TSLDKILLDE QAQWKHYLVS NISHDTVLQC HFTCSGKQES MNSNVSVYQP PRQVILTLQP TLVAVGKSFT IECRVPTVEP LDSLTLFLFR GNETLHYETF GKAAPAPQEA TATFNSTADR EDGHRNFSCL AVLDLMSRGG NIFHKHSAPK MLEIYEPVSD SQGGPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to support the adhesion of PMA-stimulated HSB2 cells to plates pre-coated with ICAM-3 Fc. The ED50for this effect is 1.0-5.0 μg/ml.Calculated Molecular Weight:48.5 kDaAccession Number:P13598Gene ID:3384原产国:USA |
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