Recombinant Human TIM-3 Fc
货号：150-20-250,150-20-100,150-20-50,150-20-500,150-20-1000,150-20-10
规格：250 ug,100 ug,50 ug,500 ug,1mg,10ug
价格：5455,3115,1390,8105,12475,570
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：T‐cell immunoglobulin mucin receptor 3 (TIM‐3), or HAVcr‐2, is a type I transmembrane receptor of the immunoglobulin superfamily involved in modulating innate and adaptive immune responses. TIM‐3 is expressed in T cells, including Th1, Th17, CD4+, CD8+, NK, and Tregs, as well as myeloid cells, including macrophages, monocytes and dendritic cells. TIM‐3 displays predominantly inhibitory functions, however recent studies have demonstrated stimulatory effects in select cell types. TIM‐3 is a relevant marker of T cell exhaustion and its expression directly correlates with chronic viral disease progression and tumor progression in a wide range of cancers. TIM‐3 expression is downregulated in autoimmune disorders such as MS, RA and psoriasis. Interaction of TIM‐3 and its ligands suppresses T cell responses and induces immune tolerance. Four ligands, Gal‐9, PtdSer, HMGB1, and Ceacam‐1, have been identified, each inducing distinct responses upon engagement. Gal‐9 ligation prompts an influx of Ca+ to the intracellular region, inducing apoptosis in T cells and NK cells. Binding PtdSer, a molecule found on the surface of apoptotic cells, promotes cross presentation of antigens and regulation of innate immune response in DCs and macrophages. HMGB1 triggers innate immune responses following interaction with nucleic acids released from dying cells; however, TIM‐3 actively competes with this interaction by attenuating immune response upon binding to HMGB1. Ceacam‐1 is co‐expressed on the cell surface with TIM‐3, where it forms heterodimers that lead to negative regulation of T cell responses. The naturally occurring human TIM‐3 monomer consists of a 181‐amino‐acid extracellular domain, a 21‐amino‐acid transmembrane domain, and a 78‐amino‐acid cytoplasmic domain. PeproTech’s CHO cell‐derived Recombinant Human TIM‐3 Fc is a glycosylated, disulfide‐linked homodimer of 412‐amino‐acid‐residues whose monomer consists of a 179‐amino acid portion of the extracellular domain fused to the 231‐amino‐acid length Fc portion of human IgG by two glycine residues. The calculated molecular weight of monomeric CHO cell‐derived Recombinant Human TIM‐3 Fc is 45.9 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 180‐200 kDa by SDS‐PAGE analysis under non‐reducing conditions.来源:CHO cells别名:T-cell immunoglobulin mucin receptor 3, HAVc r -2, TIMD-3纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to bind Recombinant human Galectin-9 in a functional ELISA assay.Calculated Molecular Weight:45.9 kDaAccession Number:Q8TDQ0Gene ID:84868原产国:USA |
©
bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://gibcohyclone.cn/thread-44725.htm
特别声明：以上内容(如有图片亦包括在内)来源于授权厂家或网络，如有侵权，请联系删除，本平台不提供信息存储服务。
Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.
QQ:1749072012