IL-23 Mouse ELISA Kit ELISA试剂盒,IL-23 Mouse ELISA Kit/小鼠IL-23 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

IL-23 Mouse ELISA Kit ELISA试剂盒,IL-23 Mouse ELISA Kit/小鼠IL-23 ELISA试剂盒

2024-10-23

IL-23 Mouse ELISA Kit/小鼠IL-23 ELISA试剂盒

货号：BMS6017,BMS6017TEN

规格：96 Tests,10X96 Tests

价格：6120,35475

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	16.0 pg/mL
检测范围	31.3-2,000 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 10 min
Homogenous (no wash)	No
批间变异系数（CV）	2.5%
批内变异系数（CV）	8.3%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	10 x 96 tests
组份	- 预包被96孔板 - 标准品 - 样品稀释液 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	IL-23 p19
Protein aliases	IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, Interleukin-23 subunit alpha
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	IL-23, Il23a, p19
Gene ID	(Mouse) 83430
Gene symbol	Il23a
UniProt ID	(Mouse) Q9EQ14

The Mouse Interleukin-23 (Ms IL-23) ELISA quantitates Ms IL-23 in mouse serum, plasma, buffered solution, or cell culture medium. The assay will exclusively recognize both natural and recombinant Ms IL-23.小鼠白介素-23（小鼠IL-23）ELISA定量检测小鼠血清，血浆，缓冲液或细胞培养基中的ILs-23。该检测试剂盒将专门识别天然和重组小鼠IL-23。Principle of the method 方法原理The Mouse IL-23 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.小鼠IL-23固相夹心ELISA（酶联免疫吸附测定）用于测量匹配的抗体对之间结合的靶标量。已在提供的微孔板的孔中预包被了靶标特异性抗体。然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每个制造批次均经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。有关验证的更多信息，请参见手册。Target information 靶标信息IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.IL-23是一种异源二聚体细胞因子，由与蛋白质p19连接的IL-12二硫键的p40亚基组成。与IL-12的p35一样，p19本身也没有生物学活性。 IL-23与IL-12Rbeta1和另一个具有STAT4结合域的新型beta2样受体亚基（称为IL-23R）相互作用。 IL-23由活化的小鼠和人树突状细胞分泌。小鼠IL-23的生物学活性不同于小鼠IL-12的生物学活性。发现小鼠IL-23不会诱导大量的IFN-γ。小鼠IL-23确实会诱导记忆T细胞（而非幼稚T细胞）强烈增殖，而IL-12对记忆细胞没有影响。此外，小鼠IL-23（但不是IL-12）可以激活小鼠记忆T细胞，以产生促炎性细胞因子IL-17。人IL-23具有与人IL-12不同的生物学特性；与IL-12相比，人IL-23诱导记忆T细胞增殖并诱导幼稚和记忆T细胞中等水平的IFN-γ产生。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

数据：

IL-23 Mouse ELISA KitRepresentative standard curve for Mouse IL-23 ELISA

技术参数

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IL-23 Mouse ELISA Kit ELISA试剂盒,IL-23 Mouse ELISA Kit/小鼠IL-23 ELISA试剂盒

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