Human IL-8 (CXCL8) (1-77) ELISA Standard Recombinant Protein/人IL-8（CXCL8）（1-77）ELISA标准重组蛋白

货号：29-8089-65

规格：4 pack

价格：1454

产品类型：标准品和抗体对

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

应用	Assay-Dependent（Ctrl）；Assay-Dependent（ELISA）
种属反应	Human
已发表种属	Not Applicable
宿主/亚型	E.coli
分类	Recombinant
类型	Protein
偶联物	Unconjugated
形式	Lyophilized
纯化类型	Affinity chromatography
内含物	no preservative
保存条件	4° C

产品详细信息Description: Human IL-8 (CXCL8) is a pro-inflammatory member of the CXC chemokine family. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in adults is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.Applications Reported: The Human IL-8 Lyophilized Standard has been reported for use in the Human IL-8 Ready-Set-Go! ELISA kit (cat. 88-8086).Applications Tested: The Human IL-8 Lyophilized Standard is intended to be used as a standard for the Human IL-8 Ready-Set-Go! ELISA kit (cat. 88-8086). Typically the standard is run in a series of 7 doubling dilutions from the 'top' standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard.Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate.Source: E. coli expressed amino acids Ser 28-Ser 99 of human IL-8 accession # NM_000584.靶标信息Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

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