VEGF Receptor 1 (Flt1) Monoclonal Antibody (Flt-19), eBioscience/VEGF受体1（Flt1）单克隆抗体（Flt-19）

货号：BMS196

规格：100 µg

价格：2787

产品类型：抗体和ELISA

品牌：eBioscience

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	Assay-Dependent（ELISA)；Assay-Dependent(IHC)；Assay-Dependent(IP)

产品详细信息Description: BMS196 reacts specifically with the extracellular domain of human VEGF Receptor-1. The epitope recognized by BMS196 resides within a.a. residues 1-251 of the VEGF-R1. The antibody does not recognize VEGF-R2.Applications Tested: ELISA, Immunohistochemistry, Immunoprecipitation.靶标信息Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.

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