eBioscience BMS326,Mouse IFN gamma Recombinant Protein, eBioscience/小鼠IFN gamma重组蛋白

2024-10-23

Mouse IFN gamma Recombinant Protein, eBioscience/小鼠IFN gamma重组蛋白

货号:BMS326

规格:100 µg

价格:5441

产品类型:蛋白表达研究

品牌:eBioscience

产品详细信息Description: Mouse IFN-gamma is a regulatory protein produced by activated NK cells and CD4+TCRalpha beta, CD8+TCR alpha beta, and TCR gamma lambda T cells. The biological activities of IFN-gamma include the specific binding to a single class of high affinity receptors. Recombinant mouse IFN-gamma is a 15.6 kDa protein containing 134 amino acid residues.Purity: >95%.Molecular Weight: 15.6 kDa.靶标信息IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
技术参数

产品应用 (Ctrl)Assay-Dependent

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
© 本文地址:https://gibcohyclone.cn/thread-46240.htm
产品询价需求提交
返回
扫码添加客服微信,咨询产品报价