Human Cyclophilin ELISA Kit ELISA试剂盒,Human Cyclophilin ELISA Kit/人亲环素ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Cyclophilin ELISA Kit ELISA试剂盒,Human Cyclophilin ELISA Kit/人亲环素ELISA试剂盒

2024-10-23

Human Cyclophilin ELISA Kit/人亲环素ELISA试剂盒

货号：EH138RB,EH138RBX5,EH138RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6143,27643,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	2.05 ng/mL
检测范围	2.05-500 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	Cyclophilin A
Protein aliases	Cyclophilin A, Cyclosporin A-binding protein, epididymis secretory sperm binding protein Li 69p, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed, peptidylprolyl isomerase A (cyclophilin A), PPIase A, Rotamase A, T cell cyclophilin
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CYPA, CYPH, HEL-S-69p, PPIA
Gene ID	(Human) 5478
Gene symbol	PPIA
UniProt ID	(Human) P62937

Human Cyclophilin quantitates human Cyclophilin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cyclophilin.人亲环素定量测定血清，血浆，上清液中的人亲环素。该检测试剂盒将专门识别天然和重组人亲环素。Target information 靶标信息Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.免疫亲和素是可溶性胞质受体家族，能够与两种主要的免疫抑制剂之一-环孢菌素A（CsA）或FK506结合。结合FK506的蛋白称为FK506结合蛋白（FKBP），结合环孢菌素A的蛋白称为亲环蛋白（CyP）。 CyP：CsA和FKBP：FK506复合物均显示抑制钙调神经磷酸酶（一种钙和钙调蛋白依赖性蛋白磷酸酶），被认为是T细胞活化中的重要信号转导酶，提供了CsA和FK506免疫抑制的可能机制。免疫亲和素起肽基脯氨酰顺反异构酶（PPIase）的作用，其活性被各自的免疫抑制剂化合物抑制。作为PPIase的亲免蛋白，通过催化含脯氨酸的蛋白质的初始折叠和重排中的缓慢步骤，可以在体内和体外加速某些蛋白质的折叠。在亲环蛋白家族中，有几种显示出高度同源性的不同蛋白质，包括CyPA，CyPB和CyPC。 CyPA，也称为CyP-18，是在所有脊椎动物组织中发现的最丰富和普遍存在的亲环蛋白，存在于T细胞中。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human Cyclophilin ELISA Kit ELISA试剂盒,Human Cyclophilin ELISA Kit/人亲环素ELISA试剂盒

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