Human MMR ELISA Kit ELISA试剂盒,Human MMR ELISA Kit/人MMR ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human MMR ELISA Kit ELISA试剂盒,Human MMR ELISA Kit/人MMR ELISA试剂盒

2024-10-24

Human MMR ELISA Kit/人MMR ELISA试剂盒

货号：EH329RB,EH329RBX5,EH329RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.41 ng/mL
检测范围	0.41-100 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	CD206 (MMR)
Protein aliases	C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CD206, hMR, Human mannose receptor, Macrophage mannose receptor 1, Macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1, MMR
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	bA541I19.1, CD206, CLEC13D, CLEC13DL, hMR, MMR, MRC1, MRC1L1
Gene ID	(Human) 4360
Gene symbol	MRC1
UniProt ID	(Human) P22897

Human MMR quantitates human MMR in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human MMR.人MMR定量测定血清，血浆，上清液中的人MMR。该检测试剂盒将专门识别天然和重组人MMR。Target information 靶标信息CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.CD206（MSR，甘露糖受体，MRC1）是一种175 kDa跨膜蛋白，属于模式识别受体。 CD206主要在组织巨噬细胞，树突状细胞，内皮细胞亚群和精子细胞中表达。 CD206被认为在先天性和适应性免疫应答中起作用。 CD206也表达在大脑的小胶质细胞和成熟细胞上，但在星形胶质细胞或神经元上不表达。 CD206还可以介导各种大分子的识别和摄取，包括修饰的脂蛋白，高级糖基化末端（AGEs）产品和淀粉样蛋白b-蛋白（Abeta）。尽管CD206的正常作用与细胞粘附和宿主防御机制有关，但它也与阿尔茨海默氏病（AD）的动脉粥样硬化和β淀粉样蛋白沉积有关。 CD206的基因编码A类巨噬细胞清除剂受体，其中包括通过选择性剪接产生的三种不同类型（1、2、3）。 1型和2型同工型是功能性受体，能够介导修饰的低密度脂蛋白（LDL）的内吞作用。尽管已显示结构域在1型和2型同工型中介导此功能，但3型同工型并未内化修饰的LDL（乙酰基LDL）。 CD206具有改变的细胞内加工过程，并被捕获在内质网中，使其无法执行内吞作用。共表达时，3型同工型可以抑制1型和2型同工型的功能，表明具有显着的负作用，并暗示了巨噬细胞中清道夫受体活性调节的机制。与CD206功能障碍有关的其他疾病包括麻风病和高雪氏病。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human MMR ELISA Kit ELISA试剂盒,Human MMR ELISA Kit/人MMR ELISA试剂盒

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