Human NRG1-alpha/HRG1-alpha ELISA Kit ELISA试剂盒,Human NRG1-alpha/HRG1-alpha ELISA Kit/人NRG1-alpha / HRG1-alpha ELISA试剂盒

2024-10-24

Human NRG1-alpha/HRG1-alpha ELISA Kit/人NRG1-alpha / HRG1-alpha ELISA试剂盒

货号:EH349RB,EH349RBX5,EH349RBX10

规格:96 tests,5X96 tests,10X96 tests

价格:6641,29884,57271

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:人

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

12 pg/mL

检测范围12.29-3,000 pg/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein nameNRG1
Protein aliasesAcetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, glial growth factor 2, Heregulin, heregulin, alpha (45kD, ERBB2 p185-activator), HRG, Neu differentiation factor, Neuregulin-1, Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, sensory and motor neuron derived factor, Sensory and motor neuron-derived factor

物种(Tested)

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene aliasesARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1, NRG1-IT2, SMDF
Gene ID(Human) 3084
Gene symbolNRG1
UniProt ID(Human) Q12780
Human NRG1-alpha/HRG1-alpha quantitates human NRG1-alpha/HRG1-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human NRG1-alpha/HRG1-alpha.人NRG1-alpha / HRG1-alpha定量检测血清,血浆,上清液中的人NRG1-alpha / HRG1-alpha。 该检测试剂盒将专门识别天然和重组人NRG1-alpha / HRG1-alpha。Target information 靶标信息Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.神经调节蛋白1(NRG1)最初被鉴定为一种44 kD糖蛋白,可与NEU / ERBB2受体酪氨酸激酶相互作用,以增加其在酪氨酸残基上的磷酸化。已知通过替代剪接从NRG1基因产生了非常多种不同的同工型。这些同工型包括调蛋白(HRG),神经胶质生长因子(GGF)以及感觉和运动神经元衍生因子(SMDF)。它们是组织特异性表达的,并且结构明显不同。 HRG同工型均包含免疫球蛋白(Ig)和表皮生长因子样(EGF样)域。 GGF和GGF2同工型包含kringle样序列以及Ig和EGF样结构域; SMDF同工型与其他同工型仅共享EGF样结构域。所有NRG1亚型的受体都是酪氨酸激酶跨膜受体ERBB家族。通过与ERBB受体相互作用,NRG1亚型可诱导上皮,神经元,神经胶质细胞和其他类型细胞的生长和分化。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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