Human ApoB ELISA Kit ELISA试剂盒,Human ApoB ELISA Kit/人ApoB ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human ApoB ELISA Kit ELISA试剂盒,Human ApoB ELISA Kit/人ApoB ELISA试剂盒

2024-10-24

Human ApoB ELISA Kit/人ApoB ELISA试剂盒

货号：EH34RB,EH34RBX5,EH34RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6327,28472,54564

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.21 ng/mL
检测范围	0.21-50 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	Apolipoprotein B
Protein aliases	Apo B-100, Apo B-48, apolipoprotein B (including Ag(x) antigen), Apolipoprotein B-100, Apolipoprotein B-48, apolipoprotein B48
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	APOB, apoB-100, apoB-48, FLDB, LDLCQ4
Gene ID	(Human) 338
Gene symbol	APOB
UniProt ID	(Human) P04114

Human ApoB quantitates human ApoB in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ApoB.人ApoB定量测定血清，血浆，上清液中的人ApoB。该检测试剂盒将专门识别天然和重组人ApoB。Target information 靶标信息Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearance of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. MDA-oxidized LDL appear to be different from LDL oxidized by other means. Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in the Apolipoprotein B gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective Apolipoprotein B, diseases affecting plasma cholesterol and Apolipoprotein B levels.人血浆中的载脂蛋白B（apo B）是低密度脂蛋白（LDL）的主要蛋白，分子量约为260-500 kDa。载脂蛋白B与细胞膜上的特定受体结合，并参与从循环中去除LDL和极低密度脂蛋白（VLDL）胆固醇。低密度脂蛋白（LDL）是血液中胆固醇的载体蛋白。 LDL与其在毛细血管壁上的受体结合，从而介导胆固醇的吸收和从循环中清除。在动脉粥样硬化病变中，发现了氧化修饰的LDL，巨噬细胞通过清除剂受体A和CD36特异性识别并摄取了氧化的LDL。氧化的低密度脂蛋白可能是动脉粥样硬化的标志物，但是氧化低密度脂蛋白的确切变化并没有得到很好的描述。 MDA氧化的LDL似乎不同于通过其他方式氧化的LDL。载脂蛋白B主要在肝脏中合成，是一种密度很低，中等密度和低密度脂蛋白（LDL）的主要载脂蛋白，也是脂蛋白的主要成分（a）。载脂蛋白B是LDL受体的配体，升高的水平与过早的动脉粥样硬化有关。血浆血浆载脂蛋白B的正常水平约为800mg / L。载脂蛋白B在血浆中以两种主要同种型出现，即apoB-48和apoB-100。载脂蛋白B的肠道和肝脏形式由来自单个非常长的mRNA的单个基因编码。这两个同工型共享一个共同的N端序列。在残基2180处的apoB-100转录本进行RNA编辑后（CAA-> UAA），产生了较短的apoB-48蛋白，从而形成了终止密码子，并提前终止了翻译。由于配体缺陷性载脂蛋白B，影响血浆胆固醇和载脂蛋白B水平的疾病，载脂蛋白B基因或其调节区中的突变会导致低脂蛋白血症，降甘油三酯血症低脂蛋白血症和高胆固醇血症。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human ApoB ELISA Kit ELISA试剂盒,Human ApoB ELISA Kit/人ApoB ELISA试剂盒

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