Human CD35 ELISA Kit ELISA试剂盒,Human CD35 ELISA Kit/人CD35 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human CD35 ELISA Kit ELISA试剂盒,Human CD35 ELISA Kit/人CD35 ELISA试剂盒

2024-10-24

Human CD35 ELISA Kit/人CD35 ELISA试剂盒

货号：EH87RB,EH87RBX5,EH87RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.2 ng/mL
检测范围	0.2-50 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	CD35
Protein aliases	C3-binding protein, C3b/C4b receptor, CD35, CD35 antigen, complement component (3b/4b) receptor 1 (Knops blood group), Complement receptor type 1, Knops blood group antigen
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	C3BR, C4BR, CD35, CR1, KN
Gene ID	(Human) 1378
Gene symbol	CR1
UniProt ID	(Human) P17927

Human CD35 quantitates human CD35 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD35.人CD35定量检测血清，血浆，上清液中的人CD35。该检测试剂盒将专门识别天然和重组人CD35。Target information 靶标信息CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.CD35（CR1，补体受体1）是细胞膜结合的单体糖蛋白，其主要功能是充当C3b和C4b的细胞受体，C3b和C4b是补体系统中最重要的成分，可清除外来大分子。 CD35蛋白介导细胞与已激活补体的颗粒和免疫复合物的结合。 CD35复合物是四种不同的同种异型（C，A，B，D），C为160 kDa； A为190 kDa； B为220 kDa，D为250 kDa。 CD35参与免疫复合物的加工，促进C3b复合物的结合和吞噬作用以及抑制补体激活。 CD35在嗜中性粒细胞，嗜酸性粒细胞，单核细胞，B细胞，一些NK细胞，红细胞，髓样白血病，滤泡树突状网状细胞上，而在嗜碱性粒细胞上阴性。 CD35蛋白表达的降低和/或其基因突变与胆囊癌，血管性毛细血管性肾小球肾炎，系统性红斑狼疮和结节病有关。 CD35基因的突变也与恶性疟原虫玫瑰花结的减少有关，赋予了抵抗严重疟疾的保护。已经表征了编码CD35的不同同工型的替代等位基因特异性剪接变体。还描述了另一种分泌形式的CD35，但尚未完全表征。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human CD35 ELISA Kit ELISA试剂盒,Human CD35 ELISA Kit/人CD35 ELISA试剂盒

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