PRDM2 Monoclonal Antibody (33AT1045)

货号：MA5-11144

规格：400 µL

价格：5547

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Purified recombinant GST fusion protein encoding a

物种：人/小鼠

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：33AT1045

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.5 mg/mL	用法：	1:100(ChIP);1:1000(WB)

产品详细信息This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2). 靶标信息PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.

数据：

PRDM2 Antibody (MA5-11144) in WB Western blot analysis using a PRDM2 monoclonal antibody (Product # MA5-11144) in lysate from PRDM2 transgenic lysate. Secondary HRP-anti-mouse was used for signal visualization with chemiluminescence. PRDM2 Antibody (MA5-11144) in CHIP ChIP analysis of estrogen target genes. (B) Time course analysis of RIZ1 binding to the pS2 gene promoter. MCF-7 cells treated with E2 for different periods of time, as indicated at the top of each lane, were processed for ChIP analysis. Immunoprecipitation was performed with RIZ1 monoclonal antibody (Product # MA5-11144) and control IgG as indicated.

推荐产品：

二抗荧光二抗免疫组化一抗标签抗体

技术参数

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://gibcohyclone.cn/thread-47003.htm