Human IkB-alpha ELISA Kit ELISA试剂盒,Human IkB-alpha ELISA Kit/人IkB-alpha ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human IkB-alpha ELISA Kit ELISA试剂盒,Human IkB-alpha ELISA Kit/人IkB-alpha ELISA试剂盒

2024-10-24

Human IkB-alpha ELISA Kit/人IkB-alpha ELISA试剂盒

货号：EH253RB,EH253RBX5,EH253RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.65 ng/mL
检测范围	0.65-150 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	IkB alpha
Protein aliases	I-kappa-B-alpha, IkappaBalpha, IkB-alpha, Major histocompatibility complex enhancer-binding protein MAD3, NF-kappa-B inhibitor alpha, nuclear factor of kappa light chain gene enhancer in B-cells, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	IKBA, MAD-3, MAD3, NFKBI, NFKBIA
Gene ID	(Human) 4792
Gene symbol	NFKBIA
UniProt ID	(Human) P25963

Human IkB-alpha quantitates human IkB-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IkB-alpha.人IkB-alpha定量检测血清，血浆，上清液中的人IkB-alpha。该检测试剂盒将专门识别天然和重组人IkB-alpha。Target information 靶标信息IkB-alpha is a 40 kDa protein that functions to inhibit NF- kappaB activity. The inhibition occurs via protein-protein interaction between I kappaB proteins and NF- kappaB dimers in the cytosol. The interaction of I kappa B-alpha with NF- kappaB masks the nuclear localization sequence of NF- kappaB, preventing NF- kappaB translocation to the nucleus. A variety of stimuli can activate gene expression by liberating NF- kappaB through the degradation of I kappaB alpha. These stimuli include the proinflammatory cytokines TNF- alpha and IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, as well as various chemical and physical stresses. In humans, the gene is located on the q arm of chromosome 14. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase alpha (IKK alpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation Serines 32 and 36. IKK alpha appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma, and each appear to make essential contributions to IkB phosphorylation.IkB-alpha是一种40 kDa的蛋白质，具有抑制NF- kappaB活性的功能。抑制是通过胞浆中IκB蛋白与NFκB二聚体之间的蛋白相互作用而发生的。 IκB-α与NFκB的相互作用掩盖了NFκB的核定位序列，防止了NFκB易位至核。多种刺激可通过I kappaBα的降解释放NF- kappaB来激活基因表达。这些刺激包括促炎细胞因子TNF-α和IL-1β，趋化因子，PMA，生长因子，LPS，紫外线照射，病毒感染以及各种化学和物理应激。在人类中，该基因位于14号染色体的q臂上。NFkB的激活要求IkB在特定的丝氨酸残基上被磷酸化，从而导致IkB的靶向降解。 IkB激酶alpha（IKK alpha），以前称为CHUK，与IkB-alpha相互作用，并在触发其降解丝氨酸32和36的位点上特异性磷酸化IkB-alpha。IKKalpha对于响应促炎性细胞因子对NFkB激活似乎至关重要。 NFkB诱导激酶（NIK）刺激了IKKB对IkB的磷酸化，该激酶本身是NFkB激活以响应TNF和IL-1的中央调节剂。功能性IKK复合物包含三个亚基，IKK alpha，IKK beta和IKK gamma，每个似乎都对IkB磷酸化做出了重要贡献。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human IkB-alpha ELISA Kit ELISA试剂盒,Human IkB-alpha ELISA Kit/人IkB-alpha ELISA试剂盒

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