Human Tryptase beta-2/TPSB2 ELISA Kit ELISA试剂盒,Human Tryptase beta-2/TPSB2 ELISA Kit/人胰蛋白酶beta-2 / TPSB2 ELISA试剂盒

2024-10-24

Human Tryptase beta-2/TPSB2 ELISA Kit/人胰蛋白酶beta-2 / TPSB2 ELISA试剂盒

货号:EH471RB,EH471RBX5,EH471RBX10

规格:96 tests,5X96 tests,10X96 tests

价格:6327,28472,57271

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:人

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

2 ng/mL

检测范围2-500 ng/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein nameTPSB2
Protein aliasesmast cell tryptase beta II, mast cell tryptase beta III, testicular tissue protein Li 163, Tryptase beta-2, Tryptase II, Tryptase-2

物种(Tested)

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene aliasesTPS2, TPSB2, tryptaseB, tryptaseC
Gene ID(Human) 64499
Gene symbolTPSB2
UniProt ID(Human) P20231
Human Tryptase beta-2/TPSB2 quantitates human Tryptase beta-2/TPSB2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Tryptase beta-2/TPSB2.人胰蛋白酶beta-2 / TPSB2定量检测血清,血浆,上清液中的人胰蛋白酶beta-2 / TPSB2。 该检测试剂盒将专门识别天然和重组人胰蛋白酶β-2/ TPSB2。Target information 靶标信息TPSB2 is a protein coding gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.TPSB2是蛋白质编码基因。类胰蛋白酶包括类胰蛋白酶丝氨酸蛋白酶,即肽酶家族S1。类胰蛋白酶仅作为肝素稳定的四聚体具有酶促活性,并且它们对所有已知的内源蛋白酶抑制剂均具有抗性。几个类胰蛋白酶基因聚集在16p13.3号染色体上。这些基因具有几个独特的特征。它们具有高度保守的3'UTR,并在5'侧翼和3'UTR处包含串联重复序列,认为它们在调节mRNA稳定性中起作用。这些基因在启动子Met密码子的紧邻上游具有一个内含子,该内含子将转录起始位点与蛋白质编码序列分开。此功能是类胰蛋白酶的特征,但在其他基因中却不常见。该基因的等位基因表现出异常数量的序列变异,因此,这些等位基因曾经被认为代表了两个独立的基因,即βII和βIII。 β类胰蛋白酶似乎是肥大细胞中表达的主要同工酶,而在嗜碱性粒细胞中,α类胰蛋白酶占主导。类胰蛋白酶被认为是哮喘以及其他变态反应性和炎性疾病发病机理的介质。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。

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