Human CD42b/GPIb-alpha ELISA Kit ELISA试剂盒,Human CD42b/GPIb-alpha ELISA Kit/人CD42b / GPIb-alpha ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human CD42b/GPIb-alpha ELISA Kit ELISA试剂盒,Human CD42b/GPIb-alpha ELISA Kit/人CD42b / GPIb-alpha ELISA试剂盒

2024-10-24

Human CD42b/GPIb-alpha ELISA Kit/人CD42b / GPIb-alpha ELISA试剂盒

货号：EH91RB,EH91RBX5,EH91RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.05 ng/mL
检测范围	0.05-10 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	CD42b
Protein aliases	Antigen CD42b-alpha, CD42b, Glycocalicin, glycoprotein Ib (platelet), alpha polypeptide, GP-Ib alpha, mutant platelet membrane glycoprotein Ib-alpha, Platelet glycoprotein Ib alpha chain, platelet membrane glycoprotein 1b-alpha subunit, platelet membrane glycoprotein Ib-alpha
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GP1BA, GPIbA, GPIbalpha, VWDP
Gene ID	(Human) 2811
Gene symbol	GP1BA
UniProt ID	(Human) P07359

Human CD42b/GPIb-alpha quantitates human CD42b/GPIb-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD42b/GPIb-alpha.人CD42b / GPIb-alpha定量检测血清，血浆，上清液中的人CD42b / GPIb-alpha。该检测试剂盒将专门识别天然和重组人CD42b / GPIb-alpha。Target information 靶标信息CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.CD42b是参与凝结过程的血小板活化标志物，是一种聚集因子。它与细胞外基质以及粘附分子相互作用。 CD42b的表达和激活似乎受VEGF和PDGF的调节。 CD42b与GPIb beta，GPIX和GPV一起构成了GPIb-IX-V受体复合物，该复合物通过将血小板束缚在血栓形成表面上，在富含血小板的血栓形成过程中起关键作用。 CD42b与在血管损伤部位暴露的血管性假血友病因子（VWF）结合，并与凝血酶，凝血因子XI和XII，高分子致激肽原，TSP-1，整联蛋白Mac-1和P-选择素结合。 CD42b的细胞外结构域通过其相互作用也有助于转移。另外，CD42b抗原在骨髓中的血小板和巨核细胞上表达。 CD42b中已描述了几种多态性和突变，其中一些是Bernard-Soulier综合征和血小板型von Willebrand病的病因。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human CD42b/GPIb-alpha ELISA Kit ELISA试剂盒,Human CD42b/GPIb-alpha ELISA Kit/人CD42b / GPIb-alpha ELISA试剂盒

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