Human Cytokeratin 18/KRT18 ELISA Kit ELISA试剂盒,Human Cytokeratin 18/KRT18 ELISA Kit/人细胞角蛋白18 / KRT18 ELISA试剂盒

2024-10-24

Human Cytokeratin 18/KRT18 ELISA Kit/人细胞角蛋白18 / KRT18 ELISA试剂盒

货号:EH145RB,EH145RBX5,EH145RBX10

规格:96 Tests,5X96 Tests,10X96 tests

价格:6641,29884,57271

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:人

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

0.164 ng/mL

检测范围0.164-40 ng/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein nameCytokeratin 18
Protein aliasesCell proliferation-inducing gene 46 protein, CK-18, cytokeratin 18, Cytokeratin-18, K18, keratin 18, type I, Keratin, type I cytoskeletal 18, Keratin-18

物种(Tested)

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene aliasesCK-18, CYK18, K18, KRT18, PIG46
Gene ID(Human) 3875
Gene symbolKRT18
UniProt ID(Human) P05783
Human CytokeRatin 18/KRT18 quantitates human Cytokeratin 18/KRT18 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cytokeratin 18/KRT18.人CytokeRatin 18 / KRT18定量测定血清,血浆,上清液中的人细胞角蛋白18 / KRT18。该检测试剂盒将专门识别天然和重组人细胞角蛋白18 / KRT18。Target information 靶标信息Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.细胞角蛋白18(角蛋白18,KRT18,I型细胞骨架18)属于低分子量角蛋白的A型(酸性)亚家族,与细胞角蛋白8结合存在。胃肠道,呼吸道和泌尿生殖道以及内分泌组织并且外分泌组织和间皮细胞对细胞角蛋白18呈阳性。此外,细胞角蛋白18主要存在于非鳞状上皮中,并存在于大多数腺癌和导管癌中,但不存在于鳞状细胞癌中。肝细胞癌仅表达细胞角蛋白8和18。细胞角蛋白18基因的突变与隐源性肝硬化有关。已经发现细胞角蛋白18基因的两个编码相同蛋白质的转录物变体。在不同类型的上皮恶性肿瘤的区分中,越来越多地使用细胞角蛋白亚型表达模式。细胞角蛋白抗体不仅有助于使用组织切片上的免疫组织化学对肿瘤进行鉴别诊断,而且还是细胞病理学和流式细胞仪检测中的有用工具。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。

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