SETD2 Polyclonal Antibody

货号：PA5-83615

规格：100 µL

价格：5702

产品类型：细胞分选

品牌：Alfa aesar

类型:	一抗	同型对照：
浓度：	0.2 mg/mL	用法：	0.25-2 µg/mL(ICC) ;0.25-2 µg/mL(IF);1:50-1:200(IHC(P))

产品详细信息Immunogen sequence: NLGMTSPLPY DSLGYNAPHH PFAGYPPGYP MQAYVDPSNP NAGKVLLPTP SMDPVCSPAP YDHAQPLVGH STEPLSAPPP VPVVPHVAAP VEVSSSQYVA 靶标信息Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

数据：

SETD2 Antibody (PA5-83615) in IF Immunofluorescent analysis of SETD2 in A-431 cells using a SETD2 polyclonal antibody (Product # PA5-83615). The analysis shows localization to nuclear speckles and cytosol. SETD2 Antibody (PA5-83615) in IHC Immunohistochemical analysis of SETD2 in human cerebellum using a SETD2 polyclonal antibody (Product # PA5-83615). The analysis shows moderate nuclear positivity in Purkinje cells as well as in cells in molecular layer.

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