Monkey IL-15 ELISA Kit ELISA试剂盒,Monkey IL-15 ELISA Kit/猴IL-15 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Monkey IL-15 ELISA Kit ELISA试剂盒,Monkey IL-15 ELISA Kit/猴IL-15 ELISA试剂盒

2024-10-24

Monkey IL-15 ELISA Kit/猴IL-15 ELISA试剂盒

货号：EP13RB,EP13RBX5,EP13RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：非人灵长类动物

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	2 pg/mL
检测范围	2.05-500 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	IL-15
物种（Tested）	非人类灵长类动物
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin

Monkey IL-15 quantitates monkey IL-15 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant monkey IL-15.猴IL-15定量分析血清，血浆，上清液中的猴IL-15。该检测试剂盒将只识别天然和重组猴IL-15。Target information 靶标信息IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.IL-15（白介素15）是一种调节T和自然杀伤细胞激活和增殖的细胞因子。 IL-15和IL-2具有许多生物学活性，因为它们都结合了常见的造血细胞生成素受体亚基，并且可能竞争同一受体，从而对彼此的活性产生负面调节。 CD8 +存储单元的数量显示受IL-15和IL-2之间的平衡控制。 IL-15诱导JAK激酶的激活，以及转录激活因子STAT3，STAT5和STAT6的磷酸化和激活。在小鼠中，研究表明IL-15可能通过STAT6的转录激活活性来增加凋亡抑制剂Bcl-xL的表达，从而阻止凋亡。 IL-15在T和B淋巴细胞，自然杀伤细胞，巨噬细胞和单核细胞的生长和分化以及许多重要的细胞内信号分子的激活中起着重要作用。因此，IL-15对于免疫应答，同种异体移植排斥反应和自身免疫性疾病的发病机制可能至关重要。此外，IL-15是广泛表达的促炎细胞因子，并已显示在多种炎性疾病中起作用，包括类风湿性关节炎，牛皮癣和肺炎性疾病。新兴数据表明，IL-15可以作为良好的治疗靶标，因为在牛皮癣和糖尿病模型中，IL-15中和作用似乎是有益的。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Monkey IL-15 ELISA Kit ELISA试剂盒,Monkey IL-15 ELISA Kit/猴IL-15 ELISA试剂盒

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