SETD8 Polyclonal Antibody

货号：PA5-31467

规格：100 µL

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fragment corresponding to a region wit

物种：其它

宿主：兔

抗体亚型：IgG1, kappa

荧光染料：Alexa Fluor 488

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:100-1:1000(ICC) ;1:100-1:1000(IF);1:100-1:1000(IHC(P));1:500-1:3000(WB)

产品详细信息Recommended positive controls: U87-MG.Predicted reactivity: Mouse (95%), Rat (93%), Bovine (95%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.

数据：

SETD8 Antibody (PA5-31467) in IFImmunofluorescent analysis of SETD8 showing staining in the nucleus of MCF-7 cells. MCF-7 cells were fixed in 4% paraformaldehyde at RT for 15 min and stained using a SETD8 polyclonal antibody (Product # PA5-31467) diluted at 1:500. Blue: Hoechst 33342 staining. SETD8 Antibody (PA5-31467) in IHC (P)Immunohistochemical analysis of SETD8 in paraffin-embedded HeLa xenograft using a SETD8 polyclonal antibody (Product # PA5-31467) at a dilution of 1:500. SETD8 Antibody (PA5-31467) in WBWestern blot analysis of SETD8 using 30 µg of U87-MG lysate. Samples were loaded onto a 10% SDS-PAGE gel and probed with a SETD8 polyclonal antibody (Product # PA5-31467) at a dilution of 1:2000.

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