JARID1A/RBP2 Polyclonal Antibody

货号：A300-897A

规格：100 µL

价格：6082

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Between 1640 and 1690

物种：人/小鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.20 mg/mL	用法：	2-10 µg/mg lysate(IP) ;1:2,000-1:10,000(WB)

产品详细信息UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

数据：

JARID1A/RBP2 Antibody (A300-897A) in WBDetection of human JARID1A/RBP2 by western blot of immunoprecipitates.Samples:Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer.Antibodies:Affinity purified rabbit anti-JARID1A/RBP2 antibody A300-897A (lot A300-897A-3) used for IP at 6 µg per reaction. JARID1A/RBP2 was also immunoprecipitated by a previous lot of this antibody (lot A300-897A-2). For blotting immunoprecipitated JARID1A/RBP2, A300-897A was used at 1 µg/ml.Detection:Chemiluminescence with an exposure time of 30 seconds.

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