L3MBTL1 Polyclonal Antibody

货号：PA5-21518

规格：100 µL

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein fragment contain a sequence co

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:100-1:1000(ICC);1:100-1:1000(IF);1:500-1:3,000(WB)

产品详细信息Recommended positive controls: HeLaS3, human L3MBTL-transfected 293T.Predicted reactivity: Mouse (88%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.

数据：

L3MBTL1 Antibody (PA5-21518) in IFImmunofluorescent analysis of L3MBTL in paraformaldehyde-fixed HeLa cells using a L3MBTL polyclonal antibody (Product # PA5-21518) at a 1:200 dilution. L3MBTL1 Antibody (PA5-21518) in WBWestern blot analysis of L3MBTL using A) 30 µg 293T whole cell lysate and B) 30 µg whole cell lysate of human L3MBTL-transfected 293T cells. Samples were loaded onto a 7.5% SDS-PAGE gel and probed with a L3MBTL polyclonal antibody (Product # PA5-21518) at a dilution of 1:5000.

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